Oxalate, the Inflammasome and Autoimmunity

Julie Matthews and Susan Owens

If you’ve been following BioIndividual Nutrition® and what we teach at the Institute, then you’ll be very familiar with oxalates… and Susan Owens.

But have you heard of the Inflammasome?

If you work with autoimmune disorders, you do not want to miss this one!

The inflammasome governs activation of inflammatory responses, through one of two very important arms of our immune system our innate immune response (and only recently discovered in 2002!)

And is now a hot topic among scientists. Look at the over 800 studies linking inflammasomes to cancer, and over 400 studies linking it to autoimmune disease, as well as heart disease, Alzheimer’s disease, Parkinson’s disease.

In this interview, Susan Owens shares her insight into how oxalate is involved with the inflammasome and autoimmune disease (as well as autism of course).

In this interview you’d discover:

  • Oxalate, gluten, zonulin and celiac disease
  • Inflammasome and disease including autoimmunity
  • Oxalate triggers the inflammasome
  • How oxalate leads to dysbiosis
  • Endogenous and exogenous oxalate
  • 73% reported the low oxalate diet having a positive effect on their autoimmune disease (source: the Oxalate Project)
  • What you can do to help: Diet and other interventions

Here’s what you get:




Purchase now and get access to the video, mp3, and notes from the interview.

Julie Matthews is a Certified Nutrition Consultant, published researcher, and accomplished author specializing in complex neurological, digestive, and immune conditions, most notably autism. Her approach is based on the BioIndividual Nutrition® needs of each person. She provides diet and nutrition guidance backed by scientific research and applied clinical experience. Her award winning book, Nourishing Hope for Autism, has helped people around the world to make food and nutrition choices that aid the health, learning, and behavior of those with autism, ADHD, and other developmental delays.

She has lectured in more than 60 cities across three continents, been on television, radio, newspaper, blogs/podcasts and more, and published scientifically referenced articles in journals and websites. Julie’s been featured by Price-Pottenger, honored by the National Association of Nutrition Professionals, sits on two scientific advisory boards including the Autism Nutrition Research Center, and is contributing author on a breakthrough scientific research study into diet and nutrition to improve autism published in 2018.She presents at leading professional conferences in the US and abroad, and is the co-founder of Nourishing Hope and BioIndividual Nutrition Institute. Julie has a private nutrition practice in San Francisco, California, and supports families and clinicians from around the world with her nutrition learning tools and professional training courses at http://NourishingHope.com and http://BioIndividualNutrition.com

Susan_Owens_OrigSusan Costen Owens has spent the last 25 years conducting research from the Dallas, Texas area looking at the biochemical issues in autism and in other disorders where oxalate is elevated. Many of these conditions also have an autoimmune component.

Working with a team in Poland, she helped characterize the frequency of oxalate issues in autism in 2011 and showed that in autism, oxalate was not associated with kidney issues. This study opened the door for exploring more conditions where oxalate is elevated but the kidney is not the focus of pathology.
Most clinical studies where oxalate is elevated fail to realize the toxicity of oxalate to the immune system, to the gut and its microbiome, and to mitochondrial function. Clarifying these scientific issues has been her main focus, as well as exploring the genetic side. She is a patient advocate at the Mountain States Regional Genetics Network, and has lectured around the world on sulfate and oxalate roles in biology. Her groups and website on the internet have helped more than 30,000 people explore the benefits of reducing oxalate. She also works closely with many scientists venturing into new scientific territory.

Susan is a graduate of Vanderbilt University, and completed her Masters degree in Interdisciplinary Studies at the University of Texas at Dallas.